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spinqualitylabelsall models PDB ID 1a96 Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image
1a96, resolution 2.00Å ()
Ligands:	, , ,
Gene:	GPT (Escherichia coli)
Activity:	Xanthine phosphoribosyltransferase, with EC number 2.4.2.22
Structural annotation: Resources: CATH : 1A96A00, 1A96B00, 1A96C00, 1A96D00 InterPro : Ipr002375, Ipr000836 Pfam : PF00156 SCOP : d1a96a_, d1a96b_, d1a96c_, d1a96d_ UniProt : P0A9M5
Functional annotation: Cellular component: cytoplasm Biological process: purine ribonucleoside salvage nucleoside metabolic process Molecular function: magnesium ion binding transferase activity protein binding xanthine phosphoribosyltransferase activity metal ion binding transferase activity, transferring glycosyl groups
Evolutionary conservation: Toggle Conservation Colors: Rows = identical sequences: Further Information: Caveats, Explanation, Complete Results at ConSurfDB
Resources:	FirstGlance, OCA, RCSB, PDBsum
Coordinates:	save as pdb, mmCIF, xml

Xanthine-guanine Phosphoribosyltransferase

Contents 1 Xanthine-guanine Phosphoribosyltransferase 2 Introduction 3 STRUCTURE 4 FUNCTION 4.1 RECOGNITION 4.2 CATALYSIS 5 IMPORTANCE 6 ADDITIONAL RESOURCES 7 References

Introduction

Xanthine-guanine Phosphoribosyltansferase (XGPRT) is one of three purine phosphoribosyltransferases (PRTases) that are part of the purine salvage pathway in Escherichia coli ^[1]; the other two PRTases in the pathway are HPRT and APRT^[1].

STRUCTURE

FUNCTION

XGRT is an enzyme that catalyzes the conversion of guanine, xanthine, and sometimes hypoxanthine, to GMP, XMP, and IMP ^[1].

=MECHANISM=

RECOGNITION

CATALYSIS

Magnesium and other divalent cations are necessary for catalysis^[1].

IMPORTANCE

spinqualitylabelsall models Insert caption here Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

ADDITIONAL RESOURCES

References

1. ↑ ^{1.0 1.1 1.2 1.3} Vos S, Parry RJ, Burns MR, de Jersey J, Martin JL. Structures of free and complexed forms of Escherichia coli xanthine-guanine phosphoribosyltransferase. J Mol Biol. 1998 Oct 2;282(4):875-89. PMID:9743633 doi:10.1006/jmbi.1998.2051