1b08
From Proteopedia
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LUNG SURFACTANT PROTEIN D (SP-D) (FRAGMENT)
Overview
BACKGROUND: Human lung surfactant protein D (hSP-D) belongs to the, collectin family of C-type lectins and participates in the innate immune, surveillance against microorganisms in the lung through recognition of, carbohydrate ligands present on the surface of pathogens. The involvement, of this protein in innate immunity and the allergic response make it the, subject of much interest. RESULTS: We have determined the crystal, structure of a trimeric fragment of hSP-D at 2.3 A resolution. The, structure comprises an alpha-helical coiled-coil and three, carbohydrate-recognition domains (CRDs). An interesting deviation from, symmetry was found in the projection of a single tyrosine sidechain into, the centre of the coiled-coil; the asymmetry of this residue influences, the orientation of one ... [(full description)]
About this Structure
1B08 is a [Single protein] structure of sequence from [Homo sapiens] with CA as [ligand]. Full crystallographic information is available from [OCA].
Reference
Crystal structure of the trimeric alpha-helical coiled-coil and the three lectin domains of human lung surfactant protein D., Hakansson K, Lim NK, Hoppe HJ, Reid KB, Structure. 1999 Mar 15;7(3):255-64. PMID:10368295
Page seeded by OCA on Mon Oct 29 18:33:40 2007
Categories: Homo sapiens | Single protein | Hakansson, K. | Hoppe, H.J. | Lim, N.K. | Reid, K.B.M. | CA | Alpha-helical coiled-coil | C-type lectin | Colectin | Crd | Lung surfactant | Sp-d
