User:Jamie Abbott/Sandbox1

From Proteopedia

proteopedia linkproteopedia link

Contents 1 Histone Acetyltransferase GCN5 2 HAT Domain 3 Bromo Domain 4 References

Histone Acetyltransferase GCN5

Histone Acetyltransferase (HAT) GCN5 is a ~94 kD (837 amino acid) protein. It is a nuclear HAT or A-type HAT.

GCN5 catalyzes the acetylation of specific Lysine residues of histones H3 and H4. Histone acetylation is an important

---

HAT Domain

The HAT domain of human GCN5 consists of amino acid residues 496-658. This domain is a mixed alpha beta structure with 7 and seven anti-parallel .

spinqualitylabelsall models Human GCN5 Histone Acetyltransferase Domain Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

Catalysis

GCN5 catalyzes the transfer of an acetyl group from acetyl coenzyme A () onto the ε-amino group of specific lysine residues present in the amino-terminal tails of each of the core histones resulting in the neutralization of a single positive charge.

---

Bromo Domain

spinqualitylabelsall models Human GCN5 Bromo Domain Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

---

References