TolR
From Proteopedia
TolR is a bitopic protein located in the inner membrane.
Structure
TolR consists of three domains: domain I, from residues 1 to 43 and including the transmembrane domain between residues 23 to 43; domain II; and domain III from residues 117 to 142.[1]
Function
Domain I is important for the interactions between TolA and TolQ, as deletion of this domain resulted in no corss-linkages formed between these proteins.[1]
Domain III of TolR has also been shown to be involved in the TolQ-TolR interaction, but not directly linked.[2] However, even when deleted there is still cross linking between TolR and TolQ showing that domain III does not affect the interaction between the two proteins, but could instead affect the function of TolR.[1] As domain III has not been shown to interact with TolA or TolQ directly, the function of TolR could be affected by domain III affecting the conformation of domain I thereby affecting the interaction between TolA/TolQ-TolR.
Therefore, domains I and III are important for the function of TolR.
