Pyrin domain

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Image:2km6.png
Crystal Structure of Pyrin domain, 2km6

Template:STRUCTURE 2km6

Pyrin domain (PYD) is a protein domain known as death fold. This domain allows the protein to interact with other pyrin domains. It is also known as PYD or PAAD/DAPIN or marenostrin domain. Proteins containing pyrin domain are involved in inflammation and apoptosis. The NALP proteins contain domains NACHT, LRR and PYD and are part of the inflammasome.

Contents

3D Structures of Pyrin domain

2km6 – hPYD in NLRP7 – human – NMR
2wl1 – hPYD PRYSPRY residues 586-776
2do9 – mPYD in NALP10 – mouse – NMR
2yu0 – mPYD in interferon-activable protein 205 - NMR
1pn5 – hPYD in NALP1 - NMR
1ucp - hPYD in apoptosis-associated speck-like protein – NMR
2hm2 – hPYD in apoptosis-associated speck-like protein2 – NMR
2dbg – hPYD in myeloid cell nuclear differentiation antigen - NMR

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Michal Harel, Joel L. Sussman

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