Group:MUZIC:Tritopodin

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spinqualitylabelsall models Prediction of the PDZ binding domain of Tritopodin . Lambert et al. ESyPred3D:Prediction of Proteins 3D structures. Bioinformatics 2002) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

TRITOPODIN

Tritopodin is the third member and less researched of the podin family proteins and is codified by the gene SYNPO2L. Tritopodin also known under the names synaptopodin 2-like, Myopodin-like and CHAP (cytoskeletal heart-enriched actin-associated protein), is found in heart (Claeys et al. 2009) ^[1] and skeletal muscle tissue (Beqqali et al. 2010) ^[2]. Tritopodin share with Myopodin 33% of homology in the Aminoacid sequence, which makes believe similar functions for both proteins. Tritopodin gene it is form by 5 exons and 2 isoforms are postulated: mCHAPa from exon 1,2,3 and 5, as well as mCHAPb that result from a start-codon in exon 4 and the two derives proteins are of 140kDa (mCHAPa) und 110kDa (mCHAPb).

Function

mCHAP is expressed in vivo and in vitro in differentiated skeletal- and heart muscle cells (Beqqali et al. 2010).

Tritopodin interactions

Tritopodin as Synaptopodin and Myopodin localizes in the sarcomeric Z-disc, where they interact with α-actinin and Filamin C, verify by CoIPs and yeast two-hybrid assays ^{[3] [4]}