Group:MUZIC:Synaptopodin
From Proteopedia
Synaptopodin
Synaptopodin, a protein encoded by the gene SYNPO [1], the founding member of a novel class of actin-associated proteins (2) and also expressed in the brain, where it is found at the postsynaptic density and the spine apparatus in a subset of telencephalic neurons (2, 4). Synaptopodin have no significant homology to any known protein except myopodin, the second member of the gene family (3).
Synaptopodin Gene and isoforms
Function
Actin-associated protein that may play a role in modulating actin-based shape and motility of dendritic spines and renal podocyte foot processes. Seems to be essential for the formation of spine apparatuses in spines of telencephalic neurons, which is involved in synaptic plasticity.
