Group:MUZIC:Zyxin

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spinqualitylabelsall models Prediction of the PDZ binding domain of Myopodin . Lambert et al. ESyPred3D:Prediction of Proteins 3D structures. Bioinformatics 2002) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

Contents 1 ZYXIN 2 Function 3 Interactions 4 References

ZYXIN

Is a protein of the zyxin/ajuba family that contains 3 LIM zinc-binding domains.

Function

Zyxin is an adhesion plaque protein, there by associates with the actin cytoskeleton near the adhesion plaques. Enters the nucleus in the presence of HESX1. Ref.1 Ref.2 It is postulate, that Zyxin may be a component of a signal transduction pathway that mediates adhesion-stimulated changes in gene expression by similarity.

Interactions

Performing yeast two-hybrid analysis system, Yu and Luo found that myopodin interacts with zyxin both in vitro and in vivo and that this interaction leads to slower migration of prostate cancer cells and reduced invasiveness (Yu YP, Luo JH, 2006). Zyxin interacts with HPV type 6 protein E6. Interacts, via the Pro-rich regions, with the EVH1 domains of ENAH, EVL and VASP. Interacts with the first LIM domain of TES. Ref.3 Ref.4 Ref.5 Ref.6 Subcellular location... Cell junction and focal adhesion...

References