Group:MUZIC:Enigma Family

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Contents 1 Enigma family: PDZ- and LIM-domain protein of the cytoskeleton 2 Enigma 3 Enigma Homologue (ENH) 4 ZASP/Cypher/Oracle 5 References

Enigma family: PDZ- and LIM-domain protein of the cytoskeleton

Proteins within the enigma subfamily typically possess an N-terminal PDZ domain (PSD 95, Disc large protein and Zonula Occludens 1) and at least one to three C-terminal LIM domain (Lin-11, Isl1 and Mec-3) within their structure. Three major proteins have extensively been described and characterized within this subfamily: Enigma, Enigma Homologue (ENH) protein and ZASP/Cypher/Oracle. These member proteins have all been located to the mammalian striated muscle, specifically in the heart and skeletal muscle Z-disk. They interact via their PDZ domains with motor protein components of the Z-disk and also recruit signalling molecules via thier LIM domain or internal motifs, for example ZM motif (ZASP motif), possibly to maintain the massive complex of interacting protein components of the muscle sarcomere for proper architecture and physiological function.

spinqualitylabelsall models NMR structure of the PDZ domain of ENH Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

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Enigma

Structure

Interactions within the Z-disk

Functions

Enigma Homologue (ENH)

Structure

Interaction within the Z-disk

Functions

ZASP/Cypher/Oracle

Structure

Interactions within the Z-disk

Functions

References

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