Group:MUZIC:Synaptopodin

From Proteopedia

Revision as of 21:41, 4 July 2011 by Eduardo Bezerra (Talk | contribs)
Jump to: navigation, search

Contents

Synaptopodin

Synaptopodin, a protein encoded by the gene SYNPO [1], the founding member of a novel class of actin-associated proteins and also expressed in the brain, where it is found at the postsynaptic density and the spine apparatus in a subset of telencephalic neurons [1] [2]. Synaptopodin have no significant homology to any known protein except myopodin, the second member of the gene family[3].

Synaptopodin isoforms

Image:Synaptopodin isoform.png


Function

Actin-associated protein that may play a role in modulating actin-based shape and motility of dendritic spines and renal podocyte foot processes. Seems to be essential for the formation of spine apparatuses in spines of telencephalic neurons, which is involved in synaptic plasticity.

References

  1. ↑ Mundel P, Heid HW, Mundel TM, Kruger M, Reiser J, Kriz W. Synaptopodin: an actin-associated protein in telencephalic dendrites and renal podocytes. J Cell Biol. 1997 Oct 6;139(1):193-204. PMID:9314539
  2. ↑ Deller T, Merten T, Roth SU, Mundel P, Frotscher M. Actin-associated protein synaptopodin in the rat hippocampal formation: localization in the spine neck and close association with the spine apparatus of principal neurons. J Comp Neurol. 2000 Mar 6;418(2):164-81. PMID:10701442
  3. ↑ Weins A, Schwarz K, Faul C, Barisoni L, Linke WA, Mundel P. Differentiation- and stress-dependent nuclear cytoplasmic redistribution of myopodin, a novel actin-bundling protein. J Cell Biol. 2001 Oct 29;155(3):393-404. Epub 2001 Oct 22. PMID:11673475 doi:10.1083/jcb.200012039

Proteopedia Page Contributors and Editors (what is this?)

Eduardo Bezerra, Michal Harel, Nikos Pinotsis

Retrieved from "http://52.214.119.220/wiki/index.php/Group:MUZIC:Synaptopodin"
Personal tools