Group:MUZIC:Zyxin

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spinqualitylabelsall models Prediction of the PDZ binding domain of Myopodin . Lambert et al. ESyPred3D:Prediction of Proteins 3D structures. Bioinformatics 2002) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

Contents 1 ZYXIN 2 Function 3 Interactions 4 References

ZYXIN

Zyxin is LIM domain protein of the zyxin/ajuba family, encode by the gene ZYX [1], that codes for a protein of 84 kDa that contains 3 LIM zinc-binding domains ^[1].

Function

Zyxin is a focal adhesion plaque protein, which associates with the actin cytoskeleton near the adhesion plaques and enters the nucleus in the presence of HESX1. Ref.1 Ref.2 It is postulate, that Zyxin may be a component of a signal transduction pathway that mediates adhesion-stimulated changes in gene expression by similarity.

Interactions

Performing yeast two-hybrid analysis system, Yu and Luo found that myopodin interacts with zyxin both in vitro and in vivo and that this interaction leads to slower migration of prostate cancer cells and reduced invasiveness (Yu YP, Luo JH, 2006). Zyxin interacts with the E6 Protein from Human Papillomavirus Type 6 and this interaction results in its nuclear translocation ^[2].

Interacts, via the Pro-rich regions, with the EVH1 domains of ENAH, EVL and VASP. Interacts with the first LIM domain of TES. Ref.3 Ref.4 Ref.5 Ref.6 Subcellular location... Cell junction and focal adhesion...

References

1. ↑ Sadler I, Crawford AW, Michelsen JW, Beckerle MC. Zyxin and cCRP: two interactive LIM domain proteins associated with the cytoskeleton. J Cell Biol. 1992 Dec;119(6):1573-87. PMID:1469049
2. ↑ Degenhardt YY, Silverstein S. Interaction of zyxin, a focal adhesion protein, with the e6 protein from human papillomavirus type 6 results in its nuclear translocation. J Virol. 2001 Dec;75(23):11791-802. PMID:11689660 doi:10.1128/JVI.75.23.11791-11802.2001