1h6h

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Image:1h6h.gif

1h6h, resolution 1.70Å

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STRUCTURE OF THE PX DOMAIN FROM P40PHOX BOUND TO PHOSPHATIDYLINOSITOL 3-PHOSPHATE

Overview

More than 50 human proteins with a wide range of functions have a 120, residue phosphoinositide binding module known as the PX domain. The 1.7 A, X-ray crystal structure of the PX domain from the p40(phox) subunit of, NADPH oxidase bound to PtdIns(3)P shows that the PX domain embraces the, 3-phosphate on one side of a water-filled, positively charged pocket and, reveals how 3-phosphoinositide specificity is achieved. A chronic, granulomatous disease (CGD)-associated mutation in the p47(phox) PX domain, that abrogates PtdIns(3)P binding maps to a conserved Arg that does not, directly interact with the phosphoinositide but instead appears to, stabilize a critical lipid binding loop. The SH3 domain present in the, full-length protein does not affect soluble PtdIns(3)P binding to the, p40(phox) PX domain.

About this Structure

1H6H is a Single protein structure of sequence from Homo sapiens with PIB and GOL as ligands. Known structural/functional Site: . Full crystallographic information is available from OCA.

Reference

The crystal structure of the PX domain from p40(phox) bound to phosphatidylinositol 3-phosphate., Bravo J, Karathanassis D, Pacold CM, Pacold ME, Ellson CD, Anderson KE, Butler PJ, Lavenir I, Perisic O, Hawkins PT, Stephens L, Williams RL, Mol Cell. 2001 Oct;8(4):829-39. PMID:11684018

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