Retinoblastoma protein

From Proteopedia

spinqualitylabelsall models PDB ID 1o9k Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image
1o9k, resolution 2.60Å ()
Related:	1pjm, 1n4m, 1h24, 1ad6, 1h25, 1gh6, 1gux, 2aze
Structural annotation: Resources: CATH : 1O9Ka00, 1O9Kb00, 1O9Kc00, 1O9Kd00, 1O9Ke00, 1O9Kf00, 1O9Kg00, 1O9Kh00 InterPro : Ipr002720, Ipr013763, Ipr002719, Ipr015030, Ipr015652, Ipr015634, Ipr003316, Ipr015633, Ipr011991 Pfam : PF01858, PF01857, PF08934 SCOP : d1o9ka_, d1o9kb_, d1o9kc_, d1o9kd_, d1o9ke_, d1o9kf_, d1o9kg_, d1o9kh_
Evolutionary conservation: Toggle Conservation Colors: Rows = identical sequences: Further Information: Caveats, Explanation, Complete Results at ConSurfDB
Resources:	FirstGlance, OCA, RCSB, PDBsum
Coordinates:	save as pdb, mmCIF, xml

Retinoblastoma Protein (pRB)

The is a tumor suppressor protein that prevents excessive cell growth. It is composed of domains A and B (add more info, size of domains, size of total protein). If not mutated, it is present in our cells and blocks the growth of dysfunctional cells between the G1 and S phase of the cell cycle before they can undergo DNA replication. pRB regulates the function of cyclin and cyclin dependent kinase complexes which are needed for the cell to proceed cell growth. Retinoblastoma protein is dependent on the transcription factor E2F, which is bound to pRB's active site when it is dephosphorylated. In viral cells, and tumorous cells pRB is dysfunctional or completely lost.