From Proteopedia
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| 1o9k, resolution 2.60Å ()
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| Related:
| 1pjm, 1n4m, 1h24, 1ad6, 1h25, 1gh6, 1gux, 2aze
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| Structural annotation:
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| Resources:
| CATH : 1O9Ka00, 1O9Kb00, 1O9Kc00, 1O9Kd00, 1O9Ke00, 1O9Kf00, 1O9Kg00, 1O9Kh00
InterPro : Ipr002720, Ipr013763, Ipr002719, Ipr015030, Ipr015652, Ipr015634, Ipr003316, Ipr015633, Ipr011991
Pfam : PF01858, PF01857, PF08934
SCOP : d1o9ka_, d1o9kb_, d1o9kc_, d1o9kd_, d1o9ke_, d1o9kf_, d1o9kg_, d1o9kh_
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| Resources:
| FirstGlance, OCA, RCSB, PDBsum
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| Coordinates:
| save as pdb, mmCIF, xml
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Retinoblastoma Protein (pRB)
The is a tumor suppressor protein that prevents excessive cell growth. It is composed of domains A and B (add more info, size of domains, size of total protein). If not mutated, it is present in our cells and blocks the growth of dysfunctional cells between the G1 and S phase of the cell cycle before they can undergo DNA replication. pRB regulates the function of cyclin and cyclin dependent kinase complexes which are needed for the cell to proceed cell growth. Retinoblastoma protein is dependent on the transcription factor E2F, which is bound to pRB's active site when it is dephosphorylated. In viral cells, and tumorous cells pRB is dysfunctional or completely lost.
pRB bound to E2F
Inhibition/ Activation of pRB
Retinoblastoma, Tumors, and Cancer
