Beta-lactamase
From Proteopedia
Beta-lactamase (Blac) are enzymes which make bacteria resitant to β-lactam antibiotics by breaking their β-lactam ring. Blac are classified according to their resistance targets. Class C are cephalosporinases; Class A are broad-spectrum; Class B are metalloenzymes; Class D are cloxacilanases.
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3D Structures of Beta-lactamase
β-lactamase class A
3dtm - EcBlac A residues 24-286 (mutant) - Escherichia coli
3c7u, 3c7v – EcBlac A (mutant) + Protein Blip
1axb - EcBlac A (mutant) + transition state analog
1tem - EcBlac A (mutant) + penicillanic acid derivative
1o7e – Blac – Stenotrophonas maltophilia
β-lactamase class B
3fcz, 3i0v, 3i11, 3i13, 3i14, 3i15 – BcBlac B - Bacillus cereus
3knr, 3kns - BcBlac C (mutant)
β-lactamase class C
3fkw, 3iwi, 3iwo, 3iwq, 3ixd – EcBlac C (mutant)
3bm6, 3fkv, 3o86, 3o87, 3o88 – EcBlac C + boronic acid derivative
3ixb, 3ixg - EcBlac C (mutant) + boronic acid derivative
3ixh - EcBlac C (mutant) + cefotaxime
3gqz, 3gr2, 3grj, 3gsg, 3gtc, 3gv9, 3gvb - EcBlac C + inhibitor
β-lactamase class D
2rl3, 1k55, 1k57, 1k4e, 1ewz, 1fof – PaBlac D – Pseudomonas aeruginosa
2hp5, 2hp6, 2hp9, 2hpb - PaBlac D (mutant)
1k6r - PaBlac D + moxalactam
1k6s - PaBlac D + phenylboronic acid
1k54 - PaBlac D + penicillanic acid derivative
1bsg – Blac – Streptomyces albus
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Michal Harel, Jaime Prilusky, Alexander Berchansky, Joel L. Sussman
