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Contents 1 Aromatase 1.1 Introduction 1.2 Function 1.3 Aromatase Inhibitors 1.4 Disorders

Aromatase

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Introduction

Aromatase is an enzyme that aids in the biosynthesis of estrogens. This enzyme helps produce this female sex hromone that helps to fuel the growth of hormone receptor-positive breast cancer. The aromatase enzyme can be found in many tissues in the body such as the brain, placenta, adipose tissue, blood vessels, gonads, endometrium, skin, and bone.

Function

Aromatase Inhibitors

Inhibitors of Aromatase stop the estrogen production in post-menopausal women. This action is done by blocking the Aromatase enzyme by turning the hormone, androgen, into small amounts of estrogen. There are three Aromatase Inhibitors that are often used in the treatment of breast cancer:

• Arimidex (Anastrozole)
• Aromasin (Exemestane)
• Femara (Letrozole)

Aromatase Inhibitors are unable to stop ovaries from producing estrogen, therefore, these inhibitors only work in post-menopausal women.

Disorders