User:User:Marcia Ivonne Peña Paz

From Proteopedia

BMAL_1

Brain and muscle Arnt like 1. Also known as MOP3

It is part of the transcriptional/translational feed back loop of the circadian timing system.

It forms an heterodimer with CLOCK or NPAS2 and both translocate into the nucleus. The heterodimer binds to E-box promoter elements of target genes.

BMAL1 and CLOCK transcription factors form and heterodimer in the cytoplasm and migrate to the nucleus where they bind to E-box promoter of target genes, acting as the positive feedback. They promote the transcription of Per and Cry genes, whose proteins form the negative feed back loop, they heterodimerize and repress CLOCK-BMAL1 complex activity.

CLOCK-BMAL1 complex regulate clock-controlled genes, modulating food intake, hormonal synthesis, body temperature and metabolism. It modulates the expression of the genes RevErbα (nuclear repressor), Dbp (D site albumin promoter)Cry 1/2, Per 1/2/3, Dbp, Rorα, Pparα, Namt, Ccg, MyoD, CKIε.