User:User:Marcia Ivonne Peña Paz

From Proteopedia

BMAL_1

Brain and muscle Arnt (aryl hydrocarbon receptor nuclear translocator)like 1. Also known as MOP3.

Bmal1 is a 626 amino acids, transcription factor of the basic helix-loop-helix (bHLH) - PAS family[1] , and a major component of both central and peripheral clock, regulating circadian rhythms.

It is part of the transcriptional/translational feed back loop of the circadian timing system.

It forms an heterodimer with CLOCK or NPAS2 and both translocate into the nucleus. The heterodimer formed in the cytoplasm migrates to the nucleus where it binds to E-box promoter of target genes, acting as the positive feedback. They promote the transcription of Per and Cry genes, whose proteins form the negative feed back loop, they heterodimerize and repress CLOCK-BMAL1 complex activity.

CLOCK-BMAL1 complex regulate clock-controlled genes, modulating food intake, hormonal synthesis, body temperature and metabolism. It modulates the expression of the genes RevErbα (nuclear repressor), Dbp (D site albumin promoter)Cry 1/2, Per 1/2/3, Dbp, Rorα, Pparα, Namt, Ccg, MyoD, CKIε.