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2iyn
From Proteopedia
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THE CO-FACTOR-INDUCED PRE-ACTIVE CONFORMATION IN PHOB
Overview
PhoB is an Escherichia coli transcription factor from a two-component, signal transduction system that is sensitive to limiting environmental, phosphate conditions. It consists of an N-terminal receiver domain (RD), and a C-terminal DNA-binding domain. The protein is activated upon, phosphorylation at the RD, an event that depends on Mg(2+) binding. The, structure of PhoB RD in complex with Mg(2+) is presented, which shows, three protomers in the asymmetric unit that interact across two different, surfaces. One association is symmetric and has been described as a, non-active dimerization contact; the other involves the, alpha4-beta5-alpha5 interface and recalls the contact found in activated, PhoB. However, here this last interaction is not perfectly symmetric and, helix alpha4, which in ... [(full description)]
About this Structure
2IYN is a [Single protein] structure of sequence from [Escherichia coli] with MG as [ligand]. Full crystallographic information is available from [OCA].
Reference
The cofactor-induced pre-active conformation in PhoB., Sola M, Drew DL, Blanco AG, Gomis-Ruth FX, Coll M, Acta Crystallogr D Biol Crystallogr. 2006 Sep;62(Pt 9):1046-57. Epub 2006, Aug 19. PMID:16929106
Page seeded by OCA on Mon Oct 29 19:46:50 2007
Categories: Escherichia coli | Single protein | Blanco, A.G. | Coll, M. | Drew, D.L. | Gomis-Ruth, F.X. | Sola, M. | MG | Activation of the pho regulon | Activator | Alpha/beta doubly wound fold | Dna- binding | Dna-binding | Gene regulation | Phosphate regulation | Phosphate transport | Phosphorylation | Sensory transduction | Transcription | Transcription factor | Transcription regulation | Transport | Two-component regulatory system
