104d
From Proteopedia
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DNA DUPLEXES FLANKED BY HYBRID DUPLEXES: THE SOLUTION STRUCTURE OF CHIMERIC JUNCTIONS IN
Overview
Hybrid duplexes and chimeric duplexes containing hybrid segments linked to, pure DNA (or pure RNA) segments are involved in transcription and, replication, as well as reverse transcription. A complete understanding of, the mechanism of these processes requires detailed information on such, duplexes and the junctions between duplexes of differing structure. Using, two-dimensional NMR, restrained molecular dynamics and mechanics, and, back-calculation refinement against the nuclear Overhauser effect spectra, at various mixing times, we have determined the solution structure of the, chimeric duplex [r(cgcg)d-(TATACGCG)]2 containing a pure DNA segment in, the center of a hybrid duplex. The solution structure differs from the, previously determined X-ray structure of the analogous duplex, ... [(full description)]
About this Structure
104D is a [Protein complex] structure of sequences from [[1]]. Full crystallographic information is available from [OCA].
Reference
DNA duplexes flanked by hybrid duplexes: the solution structure of chimeric junctions in [r(cgcg)d(TATACGCG)]2., Zhu L, Salazar M, Reid BR, Biochemistry. 1995 Feb 21;34(7):2372-80. PMID:7857947
Page seeded by OCA on Mon Oct 29 15:38:05 2007
Categories: Protein complex | Reid, B.R. | Salazar, M. | Zhu, L. | Dna | Duplex | Hybrid | Junction | Nmr | Rna
