Sandbox Reserved 429

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This Sandbox is Reserved from January 19, 2016, through August 31, 2016 for use for Proteopedia Team Projects by the class Chemistry 423 Biochemistry for Chemists taught by Lynmarie K Thompson at University of Massachusetts Amherst, USA. This reservation includes Sandbox Reserved 425 through Sandbox Reserved 439.

Contents 1 YourMacromolecule 1.1 Introduction 1.2 Overall Structure 1.3 Binding Interactions 1.4 Additional Features 1.5 Credits 1.6 References

YourMacromolecule

Introduction

spinqualitylabelsall models Insert caption here Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

Overall Structure

Binding Interactions

spinqualitylabelsall models Insert caption here Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

Outline

1. BMP7-Noggin Complex

2.Conformational changes due to binding

3. Hydrophilic and hydrophobic pockets

4. Receptor 1 & 2 and Finger 1 & 2

5. Others Antagonist of BMP 7

6. Binding affinity in comparison to others BMP families

7. Overall Summary of how binding affects overall pathways for bone formation

Additional Features

Credits

Introduction - Alec

Overall Structure - William

Drug Binding Site - Felix

Additional Features - Paula

References