1fav
From Proteopedia
|
THE STRUCTURE OF AN HIV-1 SPECIFIC CELL ENTRY INHIBITOR IN COMPLEX WITH THE HIV-1 GP41 TRIMERIC CORE
Overview
The three-dimensional structure of the complex between an HIV-1 cell-entry, inhibitor selected from screening a combinatorial library of non-natural, building blocks and the central, trimeric, coiled-coil core of HIV-1 gp41, has been determined by X-ray crystallography. The biased combinatorial, library was designed to identify ligands binding in nonpolar pockets on, the surface of the coiled-coil core of gp41. The crystal structure shows, that the non-peptide moiety of the inhibitor binds to the targeted cavity, in two different binding modes. This result suggests a strategy for, increasing inhibitor potency by use of a second-generation combinatorial, library designed to give simultaneous occupancy of both binding sites.
About this Structure
1FAV is a Single protein structure of sequence from Human immunodeficiency virus 1. Full crystallographic information is available from OCA.
Reference
The structure of an HIV-1 specific cell entry inhibitor in complex with the HIV-1 gp41 trimeric core., Zhou G, Ferrer M, Chopra R, Kapoor TM, Strassmaier T, Weissenhorn W, Skehel JJ, Oprian D, Schreiber SL, Harrison SC, Wiley DC, Bioorg Med Chem. 2000 Sep;8(9):2219-27. PMID:11026535
Page seeded by OCA on Thu Nov 8 14:02:33 2007
