1hy9
From Proteopedia
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COCAINE AND AMPHETAMINE REGULATED TRANSCRIPT
Overview
Cocaine and amphetamine regulated transcript (CART) peptide has been shown, to be an anorectic peptide that inhibits both normal and, starvation-induced feeding and completely blocks the feeding response, induced by neuropeptide Y and regulated by leptin in the hypothalamus. The, C-terminal part containing the three disulfide bridges CART(48-89) is the, biologically active part of the molecule affecting food intake. The, solution structure of the active part of CART has a fold equivalent to, other functionally distinct small proteins. CART consists mainly of turns, and loops spanned by a compact framework composed by a few small stretches, of antiparallel beta-sheet common to cystine knots.
About this Structure
1HY9 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Solution structure of the satiety factor, CART, reveals new functionality of a well-known fold., Ludvigsen S, Thim L, Blom AM, Wulff BS, Biochemistry. 2001 Aug 7;40(31):9082-8. PMID:11478874
Page seeded by OCA on Mon Nov 12 17:24:09 2007
