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Histidyl-tRNA Synthetase

Histidyl tRNA Synthetase (HisRS) is a 94kD homodimer that belongs to the Class II of aminoacyl-tRNA synthetases (aaRS). Class II enzymes have a composed of anti-parallel β-sheets and α-helices (residues 1-325).

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Function and Catalysis

Class II aminoacyl-tRNA synthetases aminoacylate the 3'OH of their cognate tRNAs.

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Mechanism

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spinqualitylabelsall models Histidyl-tRNA Synthetase Complexed with Histidyl-Adenylate Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image References