Glutamate dehydrogenase

From Proteopedia

Template:STRUCTURE 1bgv Glutamate dehydrogenase (GLDH) catalyzes the reversible conversion of glutamate to α-ketoglutarate and ammonium. The ammonia is removed via the urea cycle. Elevated GLDH values in blood serum indicate liver malfunction. NAD or NADP is a cofactor in GLDH activity. NAD is a cofactor in the forward reaction while NADP is a cofactor in the reverse. GLDH is regulated by the cell’s energy state. ATP and GTP inhibit the enzyme while ADP, GDP and leucine positively enhance it. Glutamate dehydrogenase 1 (GLDH1) catalyzes the deamination of glutamate to 2-oxoglutarate and ammonium. GLDH1 is regulated in the same manner as GLDH.

3D structures of glutamate dehydrogenase

1gtm – GLDH – Pyrococcus furiosus
1hrd – CsGLDH – Clostridium symbiosum
1aup, 1k89 – CsGLDH (mutant)
1bvu – GLDH – Thermococcus litoralis
1euz - GLDH – Thermococcus profundus
1b26 – TmGLDH – Thermotoga maritima
1b3b, 2tmg - TmGLDH (mutant)
1l1f – hGLDH1 – human
1nr1 – hGLDH1 (mutant)
1nr7 – bGLDH – bovine
3mvo, 3mvq – bGLDH1
2bma – PfGLDH – Plasmodium falciparum
3r3j - PfGLDH (mutant)
3k8z, 3k92 – GLDH (mutant) – Bacillus subtilis
2yfq - bGLDH – Peptoniphilus asaccharolyticus
3sbo, 2yfg - EcGLDH – Escherichia coli
2yfh – EcGLDH/CsGLDH

Glutamate dehydrogenase complex

1hwy – bGLDH + NAD + 2-oxoglutarate
1hwz – bGLDH + NADP + GTP + glutamate
3mw9 - bGLDH + NAD + GTP + glutamate
3ete, 3etg - bGLDH + NADP + GTP + inhibitor + glutamate
1nqt - bGLDH + ADP
1qmu - bGLDH + NADP + epicatechin-e-gallate
1bgv – CsGLDH + glutamate
1v9l - GLDH + NAD – Pyrobaculum islandicum
3aoe - TtGLDH + leucine – Thermus thermophilus
3aog - TtGLDH + NH4 + glutamate