Carboxylesterase
From Proteopedia
Carboxylesterase (CE) catalyzes the conversion of a wide variety carboxylic esters to alcohol and carboxylate. The catalytic triad of CE involves serine, glutamic acid or aspartic acid and histidine. Human CE1 (hCE1) is involved in drug metabolism and activation. It catalyzes the hydrolysis of heroin and cocaine.
CE with α,β-hydrolase fold
1auo, 1aur – CE – Pseudomonas fluorescens
3cn7, 3cn9 - CE – Pseudomonas aeruginosa
1jji – CE – Archaeoglobus fulgidus
1r1d, 2ogs, 2ogt – GsCE – Geobacillus stearothermophilus
1u4n, 2hm7 - AaCE (mutant) – Alicyclobacillus acidocaldarius
2c7b – CE – uncultured archaeon
2h1i – CE – Bacillus cereus
CE with α,β-hydrolase fold binary complex
1k4y – CE + pyridino-piperidine – rabbit
1mx5 – hCE1 + cocaine analog – human
1mx9 – hCE1 + heroin analog
1mx1 – hCE1 + tacrine
2dqy – hCE1 + cholate + palmitate
2dr0 - hCE1 + taurocholate
2dqz – hCE1 + CoA + homatropine + palmitate
2h7c - hCE1 + CoA
2hrq – hCE1 + soman
2hrr– hCE1 + tabun
3k9b – hCE1 + cyclosarin
1qz3 – AaCE (mutant) + hexadecanesulfonate
1tqh – GsCE + propyl acetate
2o7r - AeCE + propyl acetate – Actinidia eriantha
2o7v – AeCE + paraoxon
2wkw – CE + product analog - Alcaligenes
CE with β-lactamase fold
1ci9 – CE + DFP – Burkholderia gladioli
