1pdg

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Image:1pdg.gif

1pdg, resolution 3.0Å

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CRYSTAL STRUCTURE OF HUMAN PLATELET-DERIVED GROWTH FACTOR BB

Contents

Overview

The crystal structure of the homodimeric BB isoform of human recombinant, platelet-derived growth factor (PDGF-BB) has been determined by X-ray, analysis to 3.0 A resolution. The polypeptide chain is folded into two, highly twisted antiparallel pairs of beta-strands and contains an unusual, knotted arrangement of three intramolecular disulfide bonds. Dimerization, leads to the clustering of three surface loops at each end of the, elongated dimer, which most probably form the receptor recognition sites.

Disease

Known diseases associated with this structure: Dermatofibrosarcoma protuberans OMIM:[190040], Giant-cell fibroblastoma OMIM:[190040], Meningioma, SIS-related OMIM:[190040]

About this Structure

1PDG is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of human platelet-derived growth factor BB., Oefner C, D'Arcy A, Winkler FK, Eggimann B, Hosang M, EMBO J. 1992 Nov;11(11):3921-6. PMID:1396586

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