1tkt
From Proteopedia
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CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH GW426318
Overview
We have used a structure-based approach to design a novel series of, non-nucleoside inhibitors of HIV-1 RT (NNRTIs). Detailed analysis of a, wide range of crystal structures of HIV-1 RT-NNRTI complexes together with, data on drug resistance mutations has identified factors important for, tight binding of inhibitors and resilience to mutations. Using this, approach we have designed and synthesized a novel series of quinolone, NNRTIs. Crystal structure analysis of four of these compounds in complexes, with HIV-1 RT confirms the predicted binding modes. Members of this, quinolone series retain high activity against the important resistance, mutations in RT at Tyr181Cys and Leu100Ile.
About this Structure
1TKT is a Protein complex structure of sequences from Human immunodeficiency virus 1 with PO4, MG and H12 as ligands. Active as RNA-directed DNA polymerase, with EC number 2.7.7.49 Full crystallographic information is available from OCA.
Reference
Design of non-nucleoside inhibitors of HIV-1 reverse transcriptase with improved drug resistance properties. 1., Hopkins AL, Ren J, Milton J, Hazen RJ, Chan JH, Stuart DI, Stammers DK, J Med Chem. 2004 Nov 18;47(24):5912-22. PMID:15537346
Page seeded by OCA on Thu Nov 8 14:31:17 2007
