Hyaluronidase

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Template:STRUCTURE 1c82 Hyaluronidase (HU) hydrolyzes complex carbohydrates such as hyaluronan which is part of the extracellular matrix. The hydrolysis increases tissue permeability. HU is used in medicine to speed drug delivery. Hyaluronic acid (HUA) is a popular dermal filler material.

3D structures of hyaluronidase

1egu, 2brw – SpHU – Streptococcus pneumoniae
1n7n, 1n7o, 1n7p – SpHU (mutant)
1fcq, 1fcu – bHU – bee
1f1s – SaHU – Streptococcus agalactiae
2c3f, 2dp5, 2yw0, 2yx2, 2wb3, 2wh7 - SpyHU – Streptococcus pyogenes
2cbi, 2w1q, 2w1s - CpHU – Clostridium perfringens
2jnk - CpHU residues 1498-1628]] - NMR
2atm - HU – Vespula vulgaris
2pe4 – HU-1 – human

Hyaluronidase binary complex

1c82 – SpHU + HUA disaccharide
1f9g – SpHU + ascorbate
2brv– SpHU + malonate
1fcv - bHU + HUA
1i8q - SaHU + HUA disaccharide
1loh, 1lxk - SpHU + glucuronic acid
1n7q, 1n7r - SpHU (mutant) + glucuronic acid
1lxm - SaHU + glucuronic acid
1ojm, 1ojp - SpHU + condroitin disaccharide
1ojn, 1ojo - SpHU (mutant) + condroitin disaccharide
1w3y - SpHU + palmitoyl-vitamin C
2cbj - CpHU + PugNac
2j1a - CpHU + galactose
2j1e - CpHU + LacNac
2j7m, 2w1u, 2wdb - CpHU + carbohydrates
2j62 - CpHU + GlcNac-statin
2brp – SpHU + inbhibitor
2j88 - bHU + FAB
2yvv - SpyHU + lactose
3eka - SpyHU + ascorbate

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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