2ibz

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2ibz, resolution 2.3Å

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Yeast Cytochrome BC1 Complex with Stigmatellin

Overview

We describe in detail the conformations of the inhibitor stigmatellin in, its free form and bound to the ubiquinone-reducing (Q(B)) site of the, reaction center and to the ubiquinol-oxidizing (Q(o)) site of the, cytochrome bc(1) complex. We present here the first structures of a, stereochemically correct stigmatellin in complexes with a bacterial, reaction center and the yeast cytochrome bc(1) complex. The conformations, of the inhibitor bound to the two enzymes are not the same. We focus on, the orientations of the stigmatellin side-chain relative to the chromone, head group, and on the interaction of the stigmatellin side-chain with, these membrane protein complexes. The different conformations of, stigmatellin found illustrate the structural variability of the Q sites, which are affected by the same inhibitor. The free rotation about the, chi(1) dihedral angle is an essential factor for allowing stigmatellin to, bind in both the reaction center and the cytochrome bc(1) pocket.

About this Structure

2IBZ is a Protein complex structure of sequences from Mus musculus and Saccharomyces cerevisiae with HEM, FES, UQ6 and SMA as ligands. Active as Ubiquinol--cytochrome-c reductase, with EC number 1.10.2.2 Full crystallographic information is available from OCA.

Reference

A Comparison of Stigmatellin Conformations, Free and Bound to the Photosynthetic Reaction Center and the Cytochrome bc(1) Complex., Lancaster CR, Hunte C, Kelley J 3rd, Trumpower BL, Ditchfield R, J Mol Biol. 2007 Feb 11;. PMID:17337272

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