2rgf

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2rgf

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RBD OF RAL GUANOSINE-NUCLEOTIDE EXCHANGE FACTOR (PROTEIN), NMR, 10 STRUCTURES

Overview

The solution structure of the Ras-binding domain (RBD) of Ral, guanine-nucleotide exchange factor RalGEF was solved by NMR spectroscopy., The overall structure is similar to that of Raf-RBD, another effector of, Ras, although the sequence identity is only 13%. 15N chemical shifts, changes in the complex of RalGEF-RBD with Ras indicate an interaction, similar to the intermolecular beta-sheet observed for the complex between, Ras and Raf-RBD.

About this Structure

2RGF is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of the Ras-binding domain of RalGEF and implications for Ras binding and signalling., Geyer M, Herrmann C, Wohlgemuth S, Wittinghofer A, Kalbitzer HR, Nat Struct Biol. 1997 Sep;4(9):694-9. PMID:9302994

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