Ribosomal protein S15

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Image:RPS15.png
Crystal Structure of Ribosomal protein S15 from 2zm6, chain O

Template:STRUCTURE 2zm6

Ribosomal protein S15 (RPS15) is one of the 22 proteins which belong to the of the bacterial ribosome. It is involved in the early steps of ribosome assembly. The images at the left and at the right correspond to one representative RPS15, i.e. the crystal structure of Ribosomal protein S15 from Thermus thermophilus (2zm6, chain O).

3D Structures of Ribosomal protein S15

Update December 2011

S15

1a32 – RPS15 – Geobacillus stearothermophilus
1ab3, 2fkx - TtRPS15 – Thermus thermophilus - NMR
1kuq, 1f7y, 1dk1 - TtRPS15+16S RRNA fragment
2vaz – EcRPS15+RPSO mRNA operator – Escherichia coli – Cryo-EM


S15 in small ribosomal subunit

2zm6, 1n36, 1j5e, 3oto- TtRPS15 in 30S ribosomal subunit+THX+16S RRNA
2vqe, 2vqf, 2uuc, 2e5l, 2uu9, 2uua, 2uub, 3pyn, 3pyq, 3pys, 3pyu - TtRPS15 in 30S ribosomal subunit+16S RRNA+RNA fragment
3i8g, 3i8h - TtRPS15 in 30S ribosomal subunit+16S RRNA+mRNA+tRNA-Phe
3kc4 – EcRPS15 in 30S ribosomal subunit
3i1m, 3i1o, 3df1, 3df3, 2vho, 2vhp, 2avy, 2aw7, 1pnx, 3ofo, 3ofp, 3or9, 3ora, 3kc4 - EcRPS15 in 30S ribosomal subunit+16S RRNA
1i94, 1fka - TtRPS15 in 30S ribosomal subunit+16S RRNA
1p87, 1p6g - EcRPS15 in 30S ribosomal subunit+16S RRNA – Cryo-EM
3bbn - RPS15 in 30S ribosomal subunit+16S RRNA – Cryo-EM – spinach
2zkq – RPS15 in 40S ribosomal subunit+18S RRNA - dog


S15 in small + large ribosomal subunit

1ml5, 1eg0 - EcRPS15 in 30S ribosomal subunit+50S ribosomal subunit+THX+chain release factor 2+P-site tRNA+tRNA Phe+mRNA fragment+23S RRNA+5S RRNA+16S RRNA - EM


S15 in small ribosomal subunit+ chain release factor

3mr8, 3ms0 – TtRPS15 in 30S ribosomal subunit+THX+chain release factor 1+P-site tRNA+mRNA+16S RRNA
3d5a, 3d5c, 3f1e, 3f1g - TtRPS15 in 30S ribosomal subunit+THX+chain release factor 1+P-site tRNA+E-site tRNA+mRNA +16S RRNA
3zvo – TtRPS15 in 30S ribosomal subunit+THX+P-site tRNA Met +mRNA +16S RRNA+chain release factor 3
2b64 - TtRPS15 in 30S ribosomal subunit+THX+P-site tRNA Phe+E-site tRNA Phe+mRNA +16S RRNA+chain release factor 1
2b9m - TtRPS15 in 30S ribosomal subunit+THX+P-site tRNA Phe+E-site tRNA Phe+mRNA +16S RRNA+chain release factor 2
2x9r, 2x9t, 2wh1, 2wh3 - TtRPS15 in 30S ribosomal subunit+THX+chain release factor 2+P-site tRNA+mRNA +16S RRNA
3f1e, 3f1g - TtRPS15 in 30S ribosomal subunit+THX+chain release factor 2+P-site tRNA+E-site tRNA +16S RRNA


S15 in small ribosomal subunit+tRNA+mRNA

2hgi - TtRPS15 in 30S ribosomal subunit+16S RRNA+tRNA Phe+tRNA fMet
2hgp - TtRPS15 in 30S ribosomal subunit+16S RRNA+tRNA Phe+mRNA
2i2p, 2i2u - EcRPS15 in 30S ribosomal subunit+16S RRNA+tRNA Phe+mRNA
2hgr - TtRPS15 in 30S ribosomal subunit+16S RRNA+tRNA Phe+tRNA fMet+mRNA
1yl4 – TtRPS15 in 30S ribosomal subunit+ tRNA Phe+16S RRNA+THRS mRNA operator
1pns - EcRPS15 in 30S ribosomal subunit+ tRNA Phe+16S RRNA+mRNA
1xnq, 1xnr - TtRPS15 in 30S ribosomal subunit+THX+mRNA+tRNA anticodon+16S RRNA


S15 in small ribosomal subunit+A-site tRNA

2uxd, 2uxc - TtRPS15 in 30S ribosomal subunit+THX+A-site mRNA CGGG+tRNA anticodon+16S RRNA
1n32, 1n33 - TtRPS15 in 30S ribosomal subunit+THX+A-site mRNA fragment+tRNA anticodon+16S RRNA
1n34 - TtRPS15 in 30S ribosomal subunit+THX+A-site mRNA fragment +16S RRNA
1xmo, 1xmq - TtRPS15 in 30S ribosomal subunit+THX+A-site mRNA+tRNA anticodon+16S RRNA
2uxb - TtRPS15 in 30S ribosomal subunit+THX+A-site mRNA GGGU+tRNA anticodon+16S RRNA


S15 in small ribosomal subunit+P-site tRNA

3i8g - TtRPS15 in 30S ribosomal subunit+P-site tRNA+mRNA +16S RRNA
3i8h, 3i9b, 3i9d - TtRPS15 in 30S ribosomal subunit+THX+P-site tRNA+mRNA +16S RRNA
1ibk - TtRPS15 in 30S ribosomal subunit+THX+P-site mRNA fragment +16S RRNA
2wwl - EcRPS15 in 30S ribosomal subunit+Poly-Ala chain+P-site tRNA+mRNA +16S RRNA - Escherichia coli
3i1q - EcRPS15 in 30S ribosomal subunit+P-site tRNA hairpin+mRNA
3i1s, 3i1z, 3i21 - EcRPS15 in 30S ribosomal subunit+P-site tRNA hairpin+mRNA +16S RNA


S15 in small ribosomal subunit+A-site tRNA+P-site tRNA

1ibl, 1ibm - TtRPS15 in 30S ribosomal subunit+THX+A-site mRNA fragment+P-site mRNA fragment+tRNA anticodon+16S RRNA


S15 in small ribosomal subunit+P-site tRNA+E-site tRNA

2ow8 - TtRPS15 in 30S ribosomal subunit+THX+P-site tRNA Phe+E-site tRNA+mRNA +16S RRNA
2b9o - TtRPS15 in 30S ribosomal subunit+THX+P-site tRNA Phe+E-site tRNA Phe+mRNA +16S RRNA
2qnh - TtRPS15 in 30S ribosomal subunit+THX+P-site tRNA+E-site tRNA+mRNA +16S RRNA


S15 in small ribosomal subunit+A-site tRNA+P-site tRNA+E-site tRNA

2gy9, 2gyb - EcRPS15 in 30S ribosomal subunit+P-site tRNA+A-site tRNA+E-site tRNA+mRNA +16S RRNA – Cryo-EM
1jgo, 1jgp, 1jgq, 1gix - TtRPS15 in 30S ribosomal subunit+P-site tRNA+A-site tRNA+E-site tRNA+tRNA Phe+mRNA +16S RRNA
3e1a, 3e1c - EcRPS15 in 30S ribosomal subunit+P-site tRNA+A-site tRNA+E-site tRNA+mRNA +16S RRNA


S15 in small ribosomal subunit + antibiotics

1i95, 1i97, 2hhh, 2f4v, 3oge, 3ogy, 3ohc, 3ohd, 3ohy, 3oi0, 3oi2, 3oi4- TtRPS15 in 30S ribosomal subunit+16S RRNA+antibiotic
1hnw, 1hnx, 1hnz, 1fjg - TtRPS15 in 30S ribosomal subunit+16S RRNA+mRNA fragment+antibiotic
2qbb, 2qb9, 1vs5, 1vs7, 2qan, 2qal, 2qou, 2qow, 2qoy, 2qp0, 2z4k, 2z4m, 3oaq, 3oar, 3ofa, 3ofb, 3ofo, 3ofp, 3ofx, 3ofy - EcRPS15 in 30S ribosomal subunit+16S RRNA+antibiotic
2j00, 2j02 - TtRPS15 in 30S ribosomal subunit+16S RRNA+paromomycin+P-site tRNA fMet+E-site tRNA Phe+mRNA
2wdg, 2wdh, 2wdk, 2wdm - TtRPS15 in 30S ribosomal subunit+THX+P-site tRNA+E-site tRNA+mRNA +16S RRNA+tRNA Phe+paromomycin
3knj, 3knh - TtRPS15 in 30S ribosomal subunit+P-site tRNA+A-site tRNA+E-site tRNA+mRNA +16S RRNA+viomycin
3knl, 3knn - TtRPS15 in 30S ribosomal subunit+P-site tRNA+A-site tRNA+E-site tRNA+mRNA +16S RRNA+capreomycin


S15 in small ribosomal subunit + ribosome recycling factor

2qbd, 2qbf – EcRPS15 in 30S ribosomal subunit+16S RRNA+ribosome recycling factor
3r8n, 3r8o – EcRPS15 in 30S ribosomal subunit+16S RRNA+ribosome recycling factor + mRNA + tRNA
2qbh, 2qbj - EcRPS15 in 30S ribosomal subunit+16S RRNA+ribosome recycling factor+gentamicin
2v46, 2v48 - TtRPS15 in 30S ribosomal subunit+16S RRNA+ribosome recycling factor+P-site tRNA Phe+mRNA+tRNA fMet


S15 in small ribosomal subunit + elongation factor

2wri, 2wrk - TtRPS15 in 30S ribosomal subunit+THX+P-site tRNA+mRNA +16S RRNA+elongation factor G
2wrn, 2wrq - TtRPS15 in 30S ribosomal subunit+THX+A-site tRNA+mRNA +16S RRNA+elongation factor TU-4
3fic - TtRPS15 in 30S ribosomal subunit+THX+A-site tRNA+P-site tRNA+E-site tRNA+mRNA codon+16S RRNA+elongation factor TU-A
3izv – EcRPS15 in 30S ribosomal subunit+A/T-site tRNA Phe +16S RRNA+elongation factor TU
3izw – EcRPS15 in 30S ribosomal subunit+A-site tRNA Phe +mRNA +16S RRNA+elongation factor TU
2y0u, 2y0w, 2y0y, 2y10, 2y12, 2y14, 2y16, 2y18 - TtRPS15 in 30S subunit+THX+A-site tRNA+E-site tRMA+mRNA codon+16S RRNA+elongation factor TU
3fih - EcRPS15 in 30S ribosomal subunit+A-site tRNA Phe+P-site tRNA+mRNA +16S RRNA+elongation factor TU
3huw, 3huy - TtRPS15 in 30S ribosomal subunit+THX+tRNA-Met+mRNA +16S RRNA+elongation factor P
1s1h - yRPS15 in 40S ribosomal subunit+18S RRNA+elongation factor 2 – Cryo-EM – yeast


S15 in small ribosomal subunit + translation initiation factor

1i96 - TtRPS15 in 30S ribosomal subunit+THX+IF3+16S RRNA
1hr0 - TtRPS15 in 30S ribosomal subunit+THX+IF+16S RRNA


S15 in small ribosomal subunit + various proteins

3kiq, 3kis, 3kiu, 3kix - TtRPS15 in 30S ribosomal subunit+toxin RelE+16S RRNA
1voq, 1vos, 1vov, 1vox, 1voz - EcRPS15 in 30S ribosomal subunit+protein Y+16S RRNA
2xfz, 2xg1 - TtRPS15 in 30S ribosomal subunit+tRNA Phe+mRNA+colicin E3+16S RRNA
3jyv - RPS15+RPS0+RPS2+RPS3+RPS5+RPS9+RPS11+RPS13+RPS14+RPS16+RPS18+RPS20+RPS22+RPS23+RPS29+18S RRNA+RACK1+S19E+tRNA – Cryo-EM - Thermomyces lanuginosus
2ykr – EcRPS15 + 16S RRNA + GMPPNP + GTPase RSGA
4a2i – EcRPS15 + 16S RRNA + GTPase RSGA – Cryo EM

S15 in small 40S ribosomal subunit + various proteins

3iz6 - RPS15 in 40S ribosomal subunit +RACK1+18S RRNA – wheat – Cryo-EM
3o2z, 3o30 - yRPS15 in 40S ribosomal subunit +RACK1


S15 in part of small ribosomal subunit

3iy8 - EcRPS15+EcRPS5+EcRPS6+EcRPS9+EcRPS9 EcRPS8+EcRPS11+EcRPS12+EcRPS16+EcRPS17+EcRPS18+Leishmania taretolae mRNA
1g1x - TtRPS15+TtRPS6+TtRPS18+16S RRNA fragment
1qd7 – TtRPS15+TtRPS4+TtRPS5+TtRPS7+TtRPS8+TtRPS6+TtRPS17+TtRPS20+16S RRNA fragment

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Michal Harel, Alexander Berchansky, Joel L. Sussman

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