103d

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103d

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THE UNUSUAL STRUCTURE OF THE HUMAN CENTROMERE (GGA)2 MOTIF: UNPAIRED GUANOSINE RESIDUES STACKED BETWEEN SHEARED G(DOT)A PAIRS

Overview

The centromere of human chromosomes contains multiple repeats of the DNA, sequence d(TGGAA)n. This sequence has the interesting property of pairing, with itself to form stable duplexes. We have determined the solution, structure of the unusual DNA duplex 5'-TGGAATGGAA:TGGAATGGAA-3' at atomic, resolution. The duplex contains unpaired staggered guanosine residues, which co-stack by intercalation between sheared G.A and A.G base-pairs to, form an interesting new structural motif, the GA-bracketed G-stack. The, TGGAA repeat unit contains six "steps", four of which are not Watson-Crick, base-pairs.

About this Structure

103D is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.

Reference

The unusual structure of the human centromere (GGA)2 motif. Unpaired guanosine residues stacked between sheared G.A pairs., Chou SH, Zhu L, Reid BR, J Mol Biol. 1994 Dec 2;244(3):259-68. PMID:7966337

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