1a0p
From Proteopedia
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SITE-SPECIFIC RECOMBINASE, XERD
Overview
The structure of the site-specific recombinase, XerD, that functions in, circular chromosome separation, has been solved at 2.5 A resolution and, reveals that the protein comprises two domains. The C-terminal domain, contains two conserved sequence motifs that are located in similar, positions in the structures of XerD, lambda and HP1 integrases. However, the extreme C-terminal regions of the three proteins, containing the, active site tyrosine, are very different. In XerD, the arrangement of, active site residues supports a cis cleavage mechanism. Biochemical, evidence for DNA bending is encompassed in a model that accommodates, extensive biochemical and genetic data, and in which the DNA is wrapped, around an alpha-helix in a manner similar to that observed for CAP, complexed with DNA.
About this Structure
1A0P is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.
Reference
Crystal structure of the site-specific recombinase, XerD., Subramanya HS, Arciszewska LK, Baker RA, Bird LE, Sherratt DJ, Wigley DB, EMBO J. 1997 Sep 1;16(17):5178-87. PMID:9311978
Page seeded by OCA on Tue Nov 20 10:32:14 2007
