1ahk
From Proteopedia
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DER F 2, THE MAJOR MITE ALLERGEN FROM DERMATOPHAGOIDES FARINAE, NMR, MINIMIZED AVERAGE STRUCTURE
Overview
House dust mites cause heavy atopic diseases such as asthma and, dermatitis. Among allergens from Dermatophagoides farinae, Der f 2 shows, the highest positive rate for atopic patients, but its biological function, in mites has been perfectly unknown, as well as the functions of its, homologs in human and other animals. We have determined the tertiary, structure of Der f 2 by multidimensional nuclear magnetic resonance, spectroscopy. Der f 2 was found to be a single-domain protein of, immunoglobulin fold, and its structure was the most similar to those of, the two regulatory domains of transglutaminase. This fact, binding to the, bacterial surface, and other small pieces of information hinted that Der f, 2 is related to the innate antibacterial defense system in mites. The, immunoglobulin E epitopes are also discussed on the basis of the tertiary, structure.
About this Structure
1AHK is a Single protein structure of sequence from Dermatophagoides farinae. Full crystallographic information is available from OCA.
Reference
Solution structure of Der f 2, the major mite allergen for atopic diseases., Ichikawa S, Hatanaka H, Yuuki T, Iwamoto N, Kojima S, Nishiyama C, Ogura K, Okumura Y, Inagaki F, J Biol Chem. 1998 Jan 2;273(1):356-60. PMID:9417088
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