3fv7

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Image:3fv7.png

Template:STRUCTURE 3fv7

OXA-24 beta-lactamase complex with SA4-44 inhibitor

Template:ABSTRACT PUBMED 20822105

About this Structure

3fv7 is a 1 chain structure with sequence from Acinetobacter baumannii. Full crystallographic information is available from OCA.

Reference

  • Bou G, Santillana E, Sheri A, Beceiro A, Sampson JM, Kalp M, Bethel CR, Distler AM, Drawz SM, Pagadala SR, van den Akker F, Bonomo RA, Romero A, Buynak JD. Design, synthesis, and crystal structures of 6-alkylidene-2'-substituted penicillanic acid sulfones as potent inhibitors of Acinetobacter baumannii OXA-24 carbapenemase. J Am Chem Soc. 2010 Sep 29;132(38):13320-31. PMID:20822105 doi:10.1021/ja104092z
  • Santillana E, Beceiro A, Bou G, Romero A. Crystal structure of the carbapenemase OXA-24 reveals insights into the mechanism of carbapenem hydrolysis. Proc Natl Acad Sci U S A. 2007 Mar 27;104(13):5354-9. Epub 2007 Mar 20. PMID:17374723

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