3fkt

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Image:3fkt.jpg

Template:STRUCTURE 3fkt

Crystal Structure of Human Beta Secretase Complexed with Spiropiperdine Iminohydantoin Inhibitor

Template:ABSTRACT PUBMED 18811140

About this Structure

3FKT is a 1 chain structure of sequence from Homo sapiens. This structure supersedes the now removed PDB entry 3e3w. Full crystallographic information is available from OCA.

Reference

  • Barrow JC, Stauffer SR, Rittle KE, Ngo PL, Yang Z, Selnick HG, Graham SL, Munshi S, McGaughey GB, Holloway MK, Simon AJ, Price EA, Sankaranarayanan S, Colussi D, Tugusheva K, Lai MT, Espeseth AS, Xu M, Huang Q, Wolfe A, Pietrak B, Zuck P, Levorse DA, Hazuda D, Vacca JP. Discovery and X-ray crystallographic analysis of a spiropiperidine iminohydantoin inhibitor of beta-secretase. J Med Chem. 2008 Oct 23;51(20):6259-62. Epub 2008 Sep 24. PMID:18811140 doi:10.1021/jm800914n

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