2gs0

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Template:STRUCTURE 2gs0

Contents 1 NMR structure of the complex between the PH domain of the Tfb1 subunit from TFIIH and the activation domain of p53 2 Disease 3 About this Structure 4 Reference

NMR structure of the complex between the PH domain of the Tfb1 subunit from TFIIH and the activation domain of p53

Template:ABSTRACT PUBMED 16793543

Disease

Known disease associated with this structure: Adrenal cortical carcinoma OMIM:[191170], Breast cancer OMIM:[191170], Choroid plexus papilloma OMIM:[191170], Colorectal cancer OMIM:[191170], Hepatocellular carcinoma OMIM:[191170], Li-Fraumeni syndrome OMIM:[191170], Li-Fraumeni-like syndrome OMIM:[191170], Nasopharyngeal carcinoma OMIM:[191170], Osteosarcoma OMIM:[191170], Pancreatic cancer OMIM:[191170]

About this Structure

2GS0 is a 2 chains structure of sequences from Homo sapiens and Saccharomyces cerevisiae. Full experimental information is available from OCA.

Reference

• Di Lello P, Jenkins LM, Jones TN, Nguyen BD, Hara T, Yamaguchi H, Dikeakos JD, Appella E, Legault P, Omichinski JG. Structure of the Tfb1/p53 complex: Insights into the interaction between the p62/Tfb1 subunit of TFIIH and the activation domain of p53. Mol Cell. 2006 Jun 23;22(6):731-40. PMID:16793543 doi:http://dx.doi.org/10.1016/j.molcel.2006.05.007

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