1b9g
From Proteopedia
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INSULIN-LIKE-GROWTH-FACTOR-1
Contents |
Overview
Mini insulin-like growth factor 1, an inactive insulin-like growth factor, 1 mutant lacking the C region, was studied by 2D NMR spectroscopy., Resonances were assigned for almost all protons of the 57 amino acid, residues. The 3D structure of the protein was determined by distance, geometry methods. Three helical segments; Ala 8-Cys 18, Gly 42-Phe 49, and, Leu 54-Cys 61, were identified, corresponding to those present in, wild-type insulin-like growth factor 1 and in single-chain insulin. Their, relative orientation, however, was found to be changed. This change is, connected with a displacement of the Phe 23-Tyr 24-Phe 25-Asn 26, beta-strand-like segment, i.e., of aromatic side chains known to be, important for receptor binding. Thus, deletion of the C region of IGF-1, results in a substantial tertiary structural rearrangement that accounts, for the loss of receptor affinity.
Disease
Known disease associated with this structure: Growth retardation with deafness and mental retardation due to IGF1 deficiency OMIM:[147440]
About this Structure
1B9G is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Solution structure of a mini IGF-1., De Wolf E, Gill R, Geddes S, Pitts J, Wollmer A, Grotzinger J, Protein Sci. 1996 Nov;5(11):2193-202. PMID:8931138
Page seeded by OCA on Mon Nov 12 16:07:22 2007
