1bg7
From Proteopedia
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LOCALIZED UNFOLDING AT THE JUNCTION OF THREE FERRITIN SUBUNITS. A MECHANISM FOR IRON RELEASE?
Overview
How and where iron exits from ferritin for cellular use is unknown., Twenty-four protein subunits create a cavity in ferritin where iron is, concentrated >10(11)-fold as a mineral. Proline substitution for conserved, leucine 134 (L134P) allowed normal assembly but increased iron exit rates., X-ray crystallography of H-L134P ferritin revealed localized unfolding at, the 3-fold axis, also iron entry sites, consistent with shared use sites, for iron exit and entry. The junction of three ferritin subunits appears, to be a dynamic aperture with a "shutter" that cytoplasmic factors might, open or close to regulate iron release in vivo.
About this Structure
1BG7 is a Single protein structure of sequence from Rana catesbeiana with CA as ligand. Full crystallographic information is available from OCA.
Reference
Localized unfolding at the junction of three ferritin subunits. A mechanism for iron release?, Takagi H, Shi D, Ha Y, Allewell NM, Theil EC, J Biol Chem. 1998 Jul 24;273(30):18685-8. PMID:9668036
Page seeded by OCA on Tue Nov 20 11:37:34 2007
Categories: Rana catesbeiana | Single protein | Allewell, N.M. | Ha, Y. | Shi, D. | Takagi, H. | Theil, E.C. | CA | Ferritin | Iron storage
