1buy
From Proteopedia
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HUMAN ERYTHROPOIETIN, NMR MINIMIZED AVERAGE STRUCTURE
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Overview
The solution structure of human erythropoietin (EPO) has been determined, by nuclear magnetic resonance spectroscopy and the overall topology of the, protein is revealed as a novel combination of features taken from both the, long-chain and short-chain families of hematopoietic growth factors. Using, the structure and data from mutagenesis studies we have elucidated the key, physiochemical properties defining each of the two receptor binding sites, on the EPO protein. A comparison of the NMR structure of the free EPO, ligand to the receptor bound form, determined by X-ray crystallography, reveals conformational changes that may accompany receptor binding.
Disease
Known disease associated with this structure: Erythremia (1) OMIM:[133170]
About this Structure
1BUY is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
NMR structure of human erythropoietin and a comparison with its receptor bound conformation., Cheetham JC, Smith DM, Aoki KH, Stevenson JL, Hoeffel TJ, Syed RS, Egrie J, Harvey TS, Nat Struct Biol. 1998 Oct;5(10):861-6. PMID:9783743
Page seeded by OCA on Mon Nov 12 16:14:48 2007
