2vkm

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Image:2vkm.jpg

Template:STRUCTURE 2vkm

CRYSTAL STRUCTURE OF GRL-8234 BOUND TO BACE (BETA-SECRETASE)

Template:ABSTRACT PUBMED 18180160

About this Structure

2VKM is a 4 chains structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Potent memapsin 2 (beta-secretase) inhibitors: design, synthesis, protein-ligand X-ray structure, and in vivo evaluation., Ghosh AK, Kumaragurubaran N, Hong L, Kulkarni S, Xu X, Miller HB, Reddy DS, Weerasena V, Turner R, Chang W, Koelsch G, Tang J, Bioorg Med Chem Lett. 2008 Feb 1;18(3):1031-6. Epub 2008 Jan 3. PMID:18180160

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