1ruv
From Proteopedia
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RIBONUCLEASE A-URIDINE VANADATE COMPLEX: HIGH RESOLUTION RESOLUTION X-RAY STRUCTURE (1.3 A)
Overview
The X-ray crystal structure of a uridine vanadate-ribonuclease A complex, has been determined at 1.3 A resolution. The resulting structure includes, all 124 amino-acid residues, a uridine vanadate, 131 water molecules, and, a single bound 2-methyl-2-propanol. Side chains of 11 surface residues, showing discrete disorder were modeled with multiple conformations. The, final crystallographic R factor is 0.197. Structures obtained from, high-level ab initio quantum calculations of model anionic oxyvanadate, compounds were used to probe the effects of starting structure on the, refinement process and final structure of the penta-coordinate phosphorane, analog, uridine vanadate. The least-squares refinement procedure gave rise, to the same final structure of the inhibitor despite significantly, ... [(full description)]
About this Structure
1RUV is a [Single protein] structure of sequence from [Bos taurus] with UVC and TBU as [ligands]. Active as [[1]], with EC number [3.1.27.5]. Full crystallographic information is available from [OCA].
Reference
X-ray structure of a ribonuclease A-uridine vanadate complex at 1.3 A resolution., Ladner JE, Wladkowski BD, Svensson LA, Sjolin L, Gilliland GL, Acta Crystallogr D Biol Crystallogr. 1997 May 1;53(Pt 3):290-301. PMID:15299932
Page seeded by OCA on Mon Oct 29 20:58:14 2007
Categories: Bos taurus | Single protein | Gilliland, G.L. | Ladner, J.E. | Sjolin, L. | Svensson, L.A. | Wladkowski, B. | TBU | UVC | Endoribonuclease | Glycoprotein | Hydrolase | Nuclease | Signal
