2fdp

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Image:2fdp.png

Template:STRUCTURE 2fdp

Crystal structure of beta-secretase complexed with an amino-ethylene inhibitor

Template:ABSTRACT PUBMED 16451048

About this Structure

2FDP is a 3 chains structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Yang W, Lu W, Lu Y, Zhong M, Sun J, Thomas AE, Wilkinson JM, Fucini RV, Lam M, Randal M, Shi XP, Jacobs JW, McDowell RS, Gordon EM, Ballinger MD. Aminoethylenes: a tetrahedral intermediate isostere yielding potent inhibitors of the aspartyl protease BACE-1. J Med Chem. 2006 Feb 9;49(3):839-42. PMID:16451048 doi:10.1021/jm0509142

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