This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
1cdd
From Proteopedia
|
STRUCTURES OF APO AND COMPLEXED ESCHERICHIA COLI GLYCINAMIDE RIBONUCLEOTIDE TRANSFORMYLASE
Overview
The three-dimensional structure of phosphoribosylglycinamide, formyltransferase (10-formyltetrahydrofolate:5'-phosphoribosylglycinamide, formyltransferase, EC 2.1.2.2) has been solved both as an apoenzyme at, 2.8-A resolution and as a ternary complex with the substrate glycinamide, ribonucleotide and a folate inhibitor at 2.5-A resolution. The structure, is a modified doubly wound alpha/beta sheet with flexibility in the active, site, including a disordered loop in the apo structure, which is ordered, in the ternary complex structure. This enzyme is a target for anti-cancer, therapy and now for structure-based drug design.
About this Structure
1CDD is a Single protein structure of sequence from Escherichia coli with PO4 as ligand. Active as Phosphoribosylglycinamide formyltransferase, with EC number 2.1.2.2 Full crystallographic information is available from OCA.
Reference
Structures of apo and complexed Escherichia coli glycinamide ribonucleotide transformylase., Almassy RJ, Janson CA, Kan CC, Hostomska Z, Proc Natl Acad Sci U S A. 1992 Jul 1;89(13):6114-8. PMID:1631098
Page seeded by OCA on Tue Nov 20 12:21:54 2007
