3e37

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Image:3e37.jpg

Template:STRUCTURE 3e37

Protein farnesyltransferase complexed with bisubstrate ethylenediamine scaffold inhibitor 5

Template:ABSTRACT PUBMED 19246009

About this Structure

3E37 is a 2 chains structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Hast MA, Fletcher S, Cummings CG, Pusateri EE, Blaskovich MA, Rivas K, Gelb MH, Van Voorhis WC, Sebti SM, Hamilton AD, Beese LS. Structural basis for binding and selectivity of antimalarial and anticancer ethylenediamine inhibitors to protein farnesyltransferase. Chem Biol. 2009 Feb 27;16(2):181-92. PMID:19246009 doi:10.1016/j.chembiol.2009.01.014

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