1cic
From Proteopedia
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IDIOTOPE-ANTI-IDIOTOPE FAB-FAB COMPLEX; D1.3-E225
Overview
Serologically detected antigenic determinants unique to an antibody or, group of antibodies are called idiotopes. The sum of idiotopes of an, antibody constitute its idiotype. Idiotypes have been intensively studied, following a hypothesis for the self-regulation of the immune system, through a network of idiotype-anti-idiotype interactions. Furthermore, as, antigen and anti-idiotypes can competitively bind to idiotype-positive, antigen-specific antibodies, anti-idiotypes may carry an 'internal image', of the external antigen. Here we describe the structure of the complex, between the monoclonal anti-lysozyme FabD1.3 and the anti-idiotopic, FabE225 at 2.5 A resolution. This complex defines a private idiotope, consisting of 13 amino-acid residues, mainly from the, complementarity-determining regions of D1.3. Seven of these residues make, contacts with the antigen, indicating a significant overlap between, idiotope and antigen-combining site. Idiotopic mimicry of the external, antigen is not achieved at the molecular level in this example.
About this Structure
1CIC is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.
Reference
Three-dimensional structure of an idiotope-anti-idiotope complex., Bentley GA, Boulot G, Riottot MM, Poljak RJ, Nature. 1990 Nov 15;348(6298):254-7. PMID:1700305
Page seeded by OCA on Tue Nov 20 12:28:58 2007
