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1cvj
From Proteopedia
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X-RAY CRYSTAL STRUCTURE OF THE POLY(A)-BINDING PROTEIN IN COMPLEX WITH POLYADENYLATE RNA
Overview
The cocrystal structure of human poly(A)-binding protein (PABP) has been, determined at 2.6 A resolution. PABP recognizes the 3' mRNA poly(A) tail, and plays critical roles in eukaryotic translation initiation and mRNA, stabilization/degradation. The minimal PABP used in this study consists of, the N-terminal two RRM-type RNA-binding domains connected by a short, linker (RRM1/2). These two RRMs form a continuous RNA-binding trough, lined by an antiparallel beta sheet backed by four alpha helices. The, polyadenylate RNA adopts an extended conformation running the length of, the molecular trough. Adenine recognition is primarily mediated by, contacts with conserved residues found in the RNP motifs of the two RRMs., The convex dorsum of RRM1/2 displays a phylogenetically conserved, hydrophobic/acidic portion, which may interact with translation initiation, factors and regulatory proteins.
About this Structure
1CVJ is a Single protein structure of sequence from Homo sapiens with A as ligand. Full crystallographic information is available from OCA.
Reference
Recognition of polyadenylate RNA by the poly(A)-binding protein., Deo RC, Bonanno JB, Sonenberg N, Burley SK, Cell. 1999 Sep 17;98(6):835-45. PMID:10499800
Page seeded by OCA on Mon Nov 12 16:25:46 2007
