3bsc

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Template:STRUCTURE 3bsc

Crystal Structure of HCV NS5B Polymerase with a Novel Pyridazinone Inhibitor

Template:ABSTRACT PUBMED 18242088

About this Structure

3BSC is a 2 chains structure of sequences from Viruses. Full crystallographic information is available from OCA.

Reference

Novel HCV NS5B polymerase inhibitors derived from 4-(1',1'-dioxo-1',4'-dihydro-1'lambda6-benzo[1',2',4']thiadiazin-3'-yl)-5- hydroxy-2H-pyridazin-3-ones. Part 1: exploration of 7'-substitution of benzothiadiazine., Zhou Y, Webber SE, Murphy DE, Li LS, Dragovich PS, Tran CV, Sun Z, Ruebsam F, Shah AM, Tsan M, Showalter RE, Patel R, Li B, Zhao Q, Han Q, Hermann T, Kissinger CR, Lebrun L, Sergeeva MV, Kirkovsky L, Bioorg Med Chem Lett. 2008 Feb 15;18(4):1413-8. Epub 2008 Jan 8. PMID:18242088

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