1dnm

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Image:1dnm.gif

1dnm, resolution 2.500Å

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CRYSTAL STRUCTURE AND SEQUENCE-DEPENDENT CONFORMATION OF THE A.G MIS-PAIRED OLIGONUCLEOTIDE D(CGCAAGCTGGCG)

Overview

The crystal structure of the dodecanucleotide d(CGCAAGCTGGCG) has been, determined to a resolution of 2.5 A and refined to an R factor of 19.3%, for 1710 reflections. The sequence crystallizes as a B-type double helix, with two G(anti).A(syn) base pairs. These are stabilized by three-center, hydrogen bonds to pyrimidines that induce perturbations in base-pair, geometry. The central AGCT region of the helix has a wide (greater than 6, A) minor groove.

About this Structure

1DNM is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.

Reference

Crystal structure and sequence-dependent conformation of the A.G mispaired oligonucleotide d(CGCAAGCTGGCG)., Webster GD, Sanderson MR, Skelly JV, Neidle S, Swann PF, Li BF, Tickle IJ, Proc Natl Acad Sci U S A. 1990 Sep;87(17):6693-7. PMID:2395870

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